SYNDROME OF INAPPROPRIATE ANTIDIURETIC-HORMONE SECRETION IN PAPILLARYSEROUS SURFACE CARCINOMA OF THE PERITONEUM

A case of syndrome of inappropriate antidiuretic hormone secretion (SI ADH) in a patient with suboptimally cytoreduced stage III papillary se rous surface carcinoma of the peritoneum is described. After the prima ry surgery, the patient refused further therapy. Within a month bilate ral pleural effusions and abdominal ascites compelled the patient to a ccept treatment with carboplatin and cyclophosphamide. Ten days follow ing the chemotherapy, she was admitted in a disoriented state with ser um sodium of 117-mEq/L. During the evaluation, treatment, and subseque nt followup, the diagnosis of SIADH was confirmed. Numerous disease pr ocesses have been associated with the development of SIADH; however, t here have been few reports in gynecologic malignancies. Possible etiol ogy and clinical management of this patient are briefly discussed. (C) 1996 Wiley-Liss, Inc.