Authors
Citation
Vds. Bolzani et al., BIOACTIVE GUANIDINE ALKALOIDS FROM PTEROGYNE NITENS, Journal of natural products, 58(11), 1995, pp. 1683-1688
Citations number
13
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
ISSN journal
01633864
Volume
58
Issue
11
Year of publication
1995
Pages
1683 - 1688
Database
ISI
SICI code
0163-3864(1995)58:11<1683:BGAFPN>2.0.ZU;2-G
Abstract
Bioactivity-guided fractionation of a methanolic CHCl3 extract of the
leaves of Pterogyne nitens afforded the known guanidine alkaloid ptero
gynidine (2) and three new guanidine alkaloids, nitensidines A (3), B
(4), and C (5), all of which exhibited selective activity towards the
DNA repair-deficient yeast mutant RS 321 (IC12 = 9.3 - 20.0 mu g/ml);
3,4, and 5 were moderately cytotoxic to CHO Aux B-1 cells (IC50 = 8.5
- 13.0 mu g/ml).