AGASTAQUINONE, A NEW CYTOTOXIC DITERPENOID QUINONE FROM AGASTACHE RUGOSA

Authors
LEE HK OH SR KIM JI KIM JW LEE CO
Citation
Hk. Lee et al., AGASTAQUINONE, A NEW CYTOTOXIC DITERPENOID QUINONE FROM AGASTACHE RUGOSA, Journal of natural products, 58(11), 1995, pp. 1718-1721
Citations number
18
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
58
Issue
11
Year of publication
1995
Pages
1718 - 1721
Database
ISI
SICI code
0163-3864(1995)58:11<1718:AANCDQ>2.0.ZU;2-C
Abstract
A new diterpenoid quinone, agastaquinone [1], was isolated from the ro ots of Agastache rugosa. An oxime derivative [2] of agastaquinone was prepared with hydroxylamine hydrochloride. The structure of agastaquin one [1] was established as 0-norabieta-1,5(10),6,8,12-pentaene-3,11,14 -trione by spectroscopic techniques. Compounds 1 and 2 showed nonspeci fic cytotoxic activities against several human cancer cell lines in vi tro (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15).