SANTOLINDIACETYLENE, A POLYACETYLENE DERIVATIVE ISOLATED FROM THE ESSENTIAL OIL OF SANTOLINA-CANESCENS

The yield, composition, and some pharmacological activities (hepatopro tective and antioxidant) of the essential oil of Santolina canescens a erial parts have been investigated. The essential oil qualitative data were determined by gc and gc-ms. The main component, santolindiacetyl ene [1], was isolated and characterized by spectral methods, and the s tructure assigned as 1-(2'-naphthyl)hexa-2,4-diyne. The protective act ivities of the essential oil and its main component [1] were evaluated against carbon tetrachloride-induced hepatotoxicity in a rat model. I n both cases a significant hepatoprotective effect Tvas observed, as e vident from the strong decrease of elevated GPT serum levels caused by carbon tetrachloride-induced hepatic damage.