DYSLIPOPROTEINEMIA OF CHRONIC-RENAL-FAILURE - ITS RELEVANCE TO CANINEPROGRESSIVE KIDNEY-DISEASE

In dogs and humans, dyslipoproteinemia often results from renal diseas e and may contribute to the further progression of renal failure. the severity of lipoprotein abnormalities is directly proportional to the degree of renal azotemia. Dietary management and the use of cholestero l-lowering drugs may soon become important in the treatment of renal d isease in dogs. This article discusses the chemistry of lipoproteins i n humans and dogs and reviews the mechanisms by which dyslipoproteinem ia might contribute to kidney damage. Canine lipoproteins are structur ally and metabolically similar to their human counterparts, but analys is of canine lipoprotein classes is technically difficult.