Gamow was one of the pioneers who studied the possible variability of
fundamental physical constants. Some versions of modern Grand Unificat
ion theories do predict such variability. The paper is concerned with
three of the constants: the fine-structure constant, the ratio of the
proton mass m(p) to the electron mass m(e), and the ratio of cu the ne
utron mass m(p), to m(e). It is shown on the basis of the quasar spect
ra analysis, that all the three constants revealed no statistically si
gnificant variation over the last 90% of the life time of the Universe
. At the 2 sigma significance level, the following upper bounds are ob
tained for the epoch corresponding to the cosmological redshifts z sim
ilar to 2 - 3: Delta alpha/alpha < 1.5 x 10(-3), Delta m(p)/m(p) < 2 x
10(-3), and Delta m/m < 3 x 10(-4), where Delta x is a possible devia
tion of a quantity x from its present value, m = m(p)+m(n), and the nu
cleon masses are in units of m(e). (According to new observational dat
a which became known most recently, Delta m(p)/m(p) < 2 x 10(-4)). In
addition a possible anisotropy of the high-redshift fine splitting ove
r the celestial sphere is checked. Within the relative statistical err
or 3 sigma < 1% the values of alpha turned out to be the same in vario
us quadrants of the celestial sphere, which corresponds to their equal
ity in causally disconnected areas. However, at the 2 sigma level a te
ntative anisotropy of estimated Delta alpha/alpha values is found in d
irections that approximately coincide with the direction of the relic
microwave background anisotropy. The revealed constraints serve as cri
teria for selection of those theoretical models which predict variatio
n of alpha, m(p) or m(n) with the cosmological time.