EVALUATION OF GASTROINTESTINAL BEHAVIOR IN THE RAT OF AMPHIPHILIC BETA-CYCLODEXTRIN NANOCAPSULES, LOADED WITH INDOMETHACIN

With a view to investigating the role of encapsulation of indomethacin within modified beta-cyclodextrin (beta CD-C-6) nanocapsules, we prep ared nanocapsules with indomethacin as a model drug. These particles h ad an average size of 194 nm and encapsulated approximately 99% of ind omethacin. The encapsulation of indomethacin within orally administere d beta CD-C-6 nanocapsules protected against both gastric and intestin al ulceration is compared with an oral administration of an aqueous so lution of Indocid(R). The relative bioavailability was also increased by this encapsulation.