ELABORATION AND THERMAL STUDY OF INTERACTIONS BETWEEN CINNARIZINE ANDGELUCIRE(R)-53 10 PHYSICAL MIXTURES AND SOLID DISPERSIONS/

This work involves the study of elaboration and thermal characterizati on of Gelucire(R) 53/10-cinnarizine (10, 20, 30, 40 and 50% w/w cinnar izine) binary systems (solid dispersions and physical mixtures). The a nalytical thermal techniques employed, differential scanning calorimet ry (DSC) and hot stage microscopy (HSM) have demonstrated the ability of melted Gelucire(R) 53/10 to dissolve the crystals of cinnarizine. T he high solubilizing effect of this vehicle, in comparison with other carriers, may be explained on the basis of its surfactant properties. Only at low drug percentages, can the total dissolution of cinnarizine present in the system be achieved.