TREATMENT OF VAGINITIS

Objective: The purpose of this study was to evaluate the efficacy of m etronidazole 500 mg and:miconazole nitrate 100 mg (Neo-Penotran(R), Em bil Pharmacy Company, Istanbul, Turkey) in the treatment of vaginitis. Method: One hundred patients (mean age 26.5 years, range 18-50) with a clinical diagnosis of vaginitis entered this open, noncomparative st udy. Each patient inserted a Neo-Penotran(R) pessary twice daily for 1 4 days. Assessments were carried out at the beginning of the study and 15 and 22 days after the start of therapy. Sudent's t-test was used f or the statistical analysis. Results: Out of 100 patients who were ini tially recruited to the study, 20 were subsequently excluded, leaving a total of 80 patients (80%) who completed the full course of treatmen t. Vaginitis was resolved in 75% of cases, it improved in 18% and was unchanged in 7%. The success rate for the treatment of trichomoniasis was 80%, 93.4% for bacterial vaginosis and 84.4% for candidal vaginiti s. Conclusion: Neo-Penotran(R) pessaries represent a novel and effecti ve formulation for the treatment of common types of vaginitis and this pessary may also be of particular value in the treatment of resistant or recurrent vaginitis.