HOMOLOGY MODELING OF HALOALKANE DEHALOGENASE OF SFINGOMONAS-PAUCIMOBILIS UT26

The hypothetical three-dimensional structure of the enzyme 1,3,4,6-tet rachloro-1,4-cyclohexadiene hydrolase isolated from the strain Sfingom onas paucimobilis UT26 was modelled. Hydrolytic dehalogenase from anot her bacterial strain (Xanthobacter autotrophicus GJ10), previously stu died by X-ray analysis, was used as a reference structure. Differences between the residues in the active site cavity of both enzymes have b een related to their substrate activity.