ROLE OF HISTAMINE H-3 RECEPTOR ON HYPOXIA-REOXYGENATION-INDUCED CARDIAC DYSFUNCTION IN GUINEA-PIGS

Authors
AKAGI M HAMADA K NISHIOKA E FUKUISHI N AKAGI R
Citation
M. Akagi et al., ROLE OF HISTAMINE H-3 RECEPTOR ON HYPOXIA-REOXYGENATION-INDUCED CARDIAC DYSFUNCTION IN GUINEA-PIGS, Methods and findings in experimental and clinical pharmacology, 17, 1995, pp. 30-35
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
17
Year of publication
1995
Supplement
C
Pages
30 - 35
Database
ISI
SICI code
0379-0355(1995)17:<30:ROHHRO>2.0.ZU;2-U
Abstract
Hypoxia elicited a remarkable decrease in contractility and heart rate in isolated right atria from guinea pigs, a decrease which recovered partially during reoxygenation. Histamine content increased during hyp oxia and decreased during reoxygenation. However, hypoxia induced a ma rked degranulation of mast cells. Pretreatment with alpha-methylhistam ine (100-300 nM) recuperated control level contractility and heart rar e, and prevented the hypoxia-reoxygenation-induced leakage of creatine phosphokinase (CPK). On the other hand pretreatment with thioperamide (100-300 nM) decreased contractility and heart rate dose-dependently, and prevented recovery during reoxygenation. These data shows that ca rdiac histamine may play an important role in the protection against h ypoxia-reoxygenation injury through the H-3 receptor.