N. Hirasawa et K. Ohuchi, THE MECHANISM OF HISTAMINE PRODUCTION IN ALLERGIC INFLAMMATION, Methods and findings in experimental and clinical pharmacology, 17, 1995, pp. 40-45
In the air pouch-type allergic inflammation model in mrs, histamine pr
oduced in the late phase plays a role in downregulation of leukocyte i
nfiltration into the pouch fluid. In the pouch fluid, we found two kin
ds of histamine production-increasing factor (HPIF); HPIF-1, which ind
uces histamine production in bone marrow cells, and HPIF-2, which enha
nces tile activity of HPIF-1. Isoelectric point and molecular weight o
f HPIF-1 and HPIF-2 were estimated to be pi 4-5 and 25-40 kD, and pi 7
-8 and about 100 kD, respectively. The histamine-producing ability of
bone marrow cells increased after the antigen challenge, but that of p
eripheral leukocytes decreased markedly 8 h after the antigen challeng
e. Pharmacological analysis indicated that HPIF-1 induces histamine pr
oduction through activation of protein kinase C and tyrosine kinase. D
ifferentiation of bone marrow cells to histamine-producing cells by HP
IF-1 was also indicated From these observations, the histamine product
ion in the late phase of allergic inflammation is suggested to be regu
lated by the production of HPIF-1, proliferation/differentiation of hi
stamine-producing cells, and infiltration of histamine-producing cells
in blood circulation into the inflammatory site.