LISTERIOLYSIN IS A POTENT INDUCER OF THE PHOSPHATIDYLINOSITOL RESPONSE AND LIPID MEDIATOR GENERATION IN HUMAN ENDOTHELIAL-CELLS

Authors
SIBELIUS U ROSE F CHAKRABORTY T DARJI A WEHLAND J WEISS S SEEGER W GRIMMINGER F
Citation
U. Sibelius et al., LISTERIOLYSIN IS A POTENT INDUCER OF THE PHOSPHATIDYLINOSITOL RESPONSE AND LIPID MEDIATOR GENERATION IN HUMAN ENDOTHELIAL-CELLS, Infection and immunity, 64(2), 1996, pp. 674-676
Citations number
17
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
2
Year of publication
1996
Pages
674 - 676
Database
ISI
SICI code
0019-9567(1996)64:2<674:LIAPIO>2.0.ZU;2-R
Abstract
The impact of Listeria monocytogenes listeriolysin O (LLO) secretion o n phosphoinositide metabolism and mediator (platelet-activating factor and prostaglandin I-2) generation was investigated in human umbilical vein endothelial cells. Wild-type L. monocytogenes, purified LLO, and an L. innocua strain engineered to secrete LLO all elicited a strong response, whereas mutant strains defective in LLO production were inef fective. Thus, human umbilical vein endothelial cell stimulation by li steriae is linked to production of LLO.