PREVENTION OF DE-NOVO ADHESION FORMATION AFTER LAPAROSCOPIC MYOMECTOMY - A RANDOMIZED TRIAL TO EVALUATE THE EFFECTIVENESS OF AN OXIDIZED REGENERATED CELLULOSE ABSORBABLE BARRIER

To evaluate the effectiveness of the oxidized regenerated cellulose ab sorbable barrier (Interceed(R), TC7) in the prevention of de-novo adhe sion formation after laparoscopic myomectomy, a prospective and random ized study was performed at the Department of Obstetrics and Gynaecolo gy of the University of Cagliari, Cagliari, Italy, A total of 50 pre-m enopausal non-pregnant women, aged 23-42 years, who submitted to lapar oscopic myomectomy from January 1993 to June 1994, were randomized to surgery alone (control group, n = 25) or surgery and oxidized regenera ted cellulose barrier (Interceed group, n = 25), Neither group receive d any other treatment for adhesion prevention, A second-look laparosco py was performed 12-14 weeks after laparoscopic myomectomy, The incide nce of adhesion-free patients was assessed at second-look laparoscopy by an investigator not informed of the treatment, The numbers of adhes ion-free patients were three out of 25 (12%) in the control group and 15 out of 25 (60%) in the treatment group (P < 0.05), In conclusion, t he oxidized regenerated cellulose absorbable barrier significantly red uced de-novo adhesion formation after laparoscopic myomectomy.