R. Bascom et al., TOBACCO-SMOKE UPPER RESPIRATORY RESPONSE RELATIONSHIPS IN HEALTHY NONSMOKERS, Fundamental and applied toxicology, 29(1), 1996, pp. 86-93
This study determined exposure-response relationships to sidestream to
bacco smoke (2 hrs; 0, 1, 5, and 15 ppm CO) in 29 healthy nonsmoking y
oung adults, Sixteen subjects had no history of environmental tobacco
smoke rhinitis (ETS-NS) while 13 subjects had a history of ETS rhiniti
s (ETS-S), Eye irritation and odor perception showed a statistically s
ignificant exposure response in both groups; headache was significant
in ETS-S and nose irritation was significant in ETS-NS subjects. Signi
ficant postexposure (P1) symptoms were first reported at 1 ppm CO amon
g both groups, but in 3/9 symptoms were significantly greater at this
exposure level in ETS-S subjects, Nasal congestion, rhinorrhea, and co
ugh increased significantly at 15 ppm CO only, In ETS-S subjects, nasa
l volume decreased and nasal resistance increased in an exposure-respo
nse fashion, ETS-NS subjects had a qualitatively different shape to th
e exposure-response curve; significant dimensional reductions in mid-
and posterior nasal volume occurred with exposure at 1 ppm CO but not
at 5 ppm CO and reductions in posterior nasal volume occurred at 15 pp
m CO exposure, These studies indicate subjective and objective respons
e relationships with exposure to sidestream tobacco smoke at concentra
tions from 1 to 15 ppm CO, Some differences are noted among the two su
bject groups in the magnitude of some symptoms at the lowest exposure
level and in the qualitative shape of the acoustic rhinometry and nasa
l resistance exposure-response curves. (C) 1996 Society of Toxicology