ACYLFULVENES, A NEW CLASS OF POTENT ANTITUMOR AGENTS

Authors
MCMORRIS TC KELNER MJ WANG W DIAZ MA ESTES LA TAETLE R
Citation
Tc. Mcmorris et al., ACYLFULVENES, A NEW CLASS OF POTENT ANTITUMOR AGENTS, Experientia, 52(1), 1996, pp. 75-80
Citations number
19
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
52
Issue
1
Year of publication
1996
Pages
75 - 80
Database
ISI
SICI code
0014-4754(1996)52:1<75:AANCOP>2.0.ZU;2-R
Abstract
Acylfulvene, derived from the sesquiterpene illudin S by treatment wit h acid (reverse Prins reaction), is far less reactive to thiols than i lludin S. However, it is reduced readily to an aromatic product, in th e same way as illudin S. This may explain its greatly improved therape utic index compared to that of the parent compound.