The effects of glycerol ingestion (GEH) on hydration and subsequent cy
cle ergometer submaximal load exercise were examined in well condition
ed subjects. We hypothesized that GEH would reduce physiologic strain
and increase endurance. The purpose of Study I (n = 11) was to determi
ne if pre-exercise GEH (1.2 gm/kg glycerol in 26 ml/kg solution) compa
red to pre-exercise placebo hydration (PH) (26 ml/kg of aspartame flav
ored water) lowered heart rate (HR), lowered rectal temperature (T-c),
and prolonged endurance time (ET) during submaximal load cycle ergome
try. The purpose of Study II (n = 7) was to determine if the same pre-
exercise regimen followed by carbohydrate oral replacement solution (O
RS) during exercise also lowered HR, T-c, and prolonged ET. Both studi
es were double-blind, randomized, crossover trials, performed at an am
bient temperature of 23.5 - 24.5 degrees C, and humidity of 25 - 27%.
Mean HR was lower by 2.8 +/- 0.4 beats/min (p = 0.05) after CEH in Stu
dy I and by 4.4 +/- 1.1 beats/min (p = 0.01) in Study II. Endurance ti
me was prolonged after GEH in Study I (93.8 +/- 14 min vs. 77.4 +/- 9
min, p = 0.049) and in Study 11 (123.4 +/- 17 min vs. 99.0 +/- 11 min,
p = 0.03). Rectal temperature did not differ between hydration regime
ns in both Study I and Study II. Thus, pre-exercise glycerol-enhanced
hyperhydration lowers HR and prolongs ET even when combined with ORS d
uring exercise. The regimens tested in this study could potentially be
adapted for endurance activities.