The radiologic evaluation of sepsis of unknown origin has changed dram
atically since the introduction of cross-sectional imaging. Interventi
onal procedures such as abscess drainage, cholecystostomy, biliary dra
inage, nephrostomy, and fluid aspiration have reduced the morbidity an
d mortality associated with occult sources of sepsis. This article exa
mines some of the common etiologies and treatments of sepsis in the ho
spitalized patient.