ORNITHINE DECARBOXYLASE ANTIZYME - A NOVEL TYPE OF REGULATORY PROTEIN

Authors
HAYASHI S MURAKAMI Y MATSUFUJI S
Citation
S. Hayashi et al., ORNITHINE DECARBOXYLASE ANTIZYME - A NOVEL TYPE OF REGULATORY PROTEIN, Trends in biochemical sciences, 21(1), 1996, pp. 27-30
Citations number
48
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
21
Issue
1
Year of publication
1996
Pages
27 - 30
Database
ISI
SICI code
0968-0004(1996)21:1<27:ODA-AN>2.0.ZU;2-N
Abstract
Antizyme plays an important regulatory role in the synthesis of ornith ine decarboxylase (ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating polyamine uptake, antizyme is induce d by polyamine-enhanced translational frameshifting, and binds to ODC, accelerating its ATP-dependent degradation, a process catalysed by th e 26S proteasome.