We describe three sisters in a family who presented with a clinical fo
rm of osteomesopycnosis which is a rare, benign osteosclerotic bone di
sorder limited to the axial skeleton. It must be distinguished from ot
her osteosclerotic conditions which carry a worse prognosis, This is t
he first report of the condition in a Japanese family, and we believe
it to be the first to be identified in Asian races.