SYNTHESIS OF 2,5-DISUBSTITUTED-1,3,4-OXADIAZOLE, 1,5-DISUBSTITUTED-2-MERCAPTO-1,3,4-TRIAZOLE AND 2,5-DISUBSTITUTED-1,3,4-THIADIAZOLE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS

p-Nitrosothymoxyacetic acid hydrazide 1 has been synthesised from ethy l p-nitrosothymoxy acetate on condensation with hydrazine hydrate. Com pound 1 on treatment with arylisocyanates yields its thiosemicarbazide s 2. Compounds 2 on chemoselective heterocyclization with NaOH/I-2, Na OH and Conc. H2SO4 respectively, afford amino-5-(p-nitrosothymoxymethy l)-1,3,4-oxadiazoles (3), mercapto5-(p-nitrosothymoxymethyl)-1,3,4-tri azoles (4) and 2-arylamino-5-(p-nitrosothymoxymethyl)-1, thiadiazoles (5). Compounds 2-5 along with their derivatives have been screened for their antimicrobial activity.