Rm. Schwartzman et al., THE MEXICAN-HAIRLESS DOG AS A MODEL FOR ASSESSING THE COMEDOLYTIC ANDMORPHOGENIC ACTIVITY OF RETINOIDS, British journal of dermatology, 134(1), 1996, pp. 64-70
The skin of the Mexican hairless dog is covered with comedones, and th
is animal therefore provides a potentially useful model to assess the
comedolytic activity of topical anti-acne drugs. We treated an animal
with three different formulations of tretinoin for a 14-week period, a
nd all produced a similar clinical response. There was a striking redu
ction in the number of comedones, and the skin became lighter and more
uniform in colour. Histological changes were similar to those reporte
d in humans treated with tretinoin, but a novel finding was incomplete
neogenesis of hair follicles. We suggest that the Mexican hairless do
g may be a useful model for screening novel molecules for retinoid act
ivity.