The need for chemoprophylaxis for bacterial endocarditis is partly dep
endent on the risk of bacteraemia associated with the procedure, which
has not been adequately defined for skin surgery. The incidence of po
stoperative bacteraemia in 149 immunocompetent out-patients with nonin
fected lesions was 0.7% (95% CI 0.3-3.8%). Procedures included excisio
ns, flaps, grafts and micrographically controlled surgery. Coagulase-n
egative staphylococcus was the most common skin isolate at the site of
surgery, present in 68.5% of patients. The most: effective chemoproph
ylaxis would be intravenous vancomycin, which is inconvenient and has
an inherent risk of morbidity. Given the low incidence of bacteraemia
and the disadvantages of the optimum chemoprophylaxis, surgery on non-
infected lesions does not warrant prophylactic antibiotics to prevent
the very low risk of bacterial endocarditis.