CHROMOSOMAL LOCALIZATION AND 5'-SEQUENCE OF THE HUMAN PROTEIN-SERINE THREONINE PHOSPHATASE-5' GENE

Protein phosphorylation plays a crucial role in the regulation of a wi de array of proteins involved in many cellular processes. Protein phos phatase 5 (PP5) is a novel member of the protein serine/threonine phos phatase family. The majority of the cDNA sequence of PP5 has been repo rted recently. In our study, a sequence encoding the whole open readin g frame of PP5 was cloned from a human fetal brain cDNA library. The p rotein phosphatase cDNA sequence of our clone is longer at the 5' end than the recently published sequence. It's likely that the extended se quence contains the start codon ATG, since a translation stop codon TA G is present upstream of the ATG codon in the same open reading frame. The mRNA of the PP5 gene was detected in all the human tissues examin ed. The PP5 gene was localized to human chromosomal region 19q13.3. (C ) 1996 Academic Press. Inc.