UTERINE NEOPLASMS IN PATIENTS TREATED WITH TAMOXIFEN

Since 1985, when Killackey originally described three cases of endomet rial carcinoma in patients receiving tamoxifen, there have been severa l reports confirming or denying the relationship between tamoxifen and endometrial carcinoma. Our study of 15 patients treated for breast ca rcinoma with tamoxifen found that papillary serous carcinoma was the m ost common tumor in this group of patients. Several other retrospectiv e studies reported a high incidence of high-grade endometrioid adenoca rcinoma or high-risk variants of endometrial carcinoma in patients rec eiving tamoxifen. (C) 1995 Wiley-Liss, Inc.