C. Libetta et al., INFLAMMATORY EFFECTS OF PERITONEAL-DIALYSIS - EVIDENCE OF SYSTEMIC MONOCYTE ACTIVATION, Kidney international, 49(2), 1996, pp. 506-511
We evaluated in peritonitis-free patients undergoing continuous ambula
tory peritoneal dialysis (CAPD) the release of both interleukin-6 (IL-
6) and beta-2-microglobulin (beta(2)m) by cultured peripheral blood mo
nonuclear cells (PBMC), as well as the levels of serum amyloid A (SAA)
, that is, the main hepatic acute phase protein during inflammation. T
he same measurements were obtained in hemodialysis (HD) patients, urem
ic non-dialyzed patients (ESRD) and healthy controls (CON). In CAPD, I
L-6 production from PBMC was markedly increased in comparison to the c
ontrol value (600.7 +/- 104.3 vs. 14.2 +/- 3.6 pg/3 x 10(6) PBMC/24 hr
, P < 0.005). Similarly, a striking enhancement of the PBMC release of
beta(2)m was detected in CAPD with respect to CON (10.1 +/- 2.6 vs. 0
.063 +/- 0.013 mu g/3 x 10(6) PBMC/24 hr, P < 0.001). Also, the SAA le
vels were significantly greater in CAPD patients (21.3 +/- 8.7 mu g/dl
) than in controls (3.14 +/- 0.17 mu g/dl, P < 0.05). Analogous increa
ses of both IL-6 and beta(2)m cell releases, as well as of SAA levels,
were observed in HD patients. No difference concerning the three para
meters was detected between CON and ESRD. In conclusion, CAPD induces
per se PBMC activation with an enhanced release of both IL-6 and beta(
2)m; this is associated to higher levels of SAA. These systemic inflam
matory effects are comparable to those observed in HD patients indicat
ing that CAPD is similar to HD in terms of biocompatibility of the tre
atment.