IMPROVED PREPARATION OF PHOSPHINATE ESTERS FOR PALLADIUM-CATALYZED CROSS-COUPLING

Authors
SCHWABACHER AW STEFANESCU AD
Citation
Aw. Schwabacher et Ad. Stefanescu, IMPROVED PREPARATION OF PHOSPHINATE ESTERS FOR PALLADIUM-CATALYZED CROSS-COUPLING, Tetrahedron letters, 37(4), 1996, pp. 425-428
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
4
Year of publication
1996
Pages
425 - 428
Database
ISI
SICI code
0040-4039(1996)37:4<425:IPOPEF>2.0.ZU;2-N
Abstract
The reaction between phosphinic acid and trimethyl orthoformate to yie ld methyl phosphinate shows a pronounced solvent dependence. Condition s are defined to improve ester purity. t-Butyl phosphinate is also pre pared cleanly, and its palladium-catalyzed reaction with aryl iodide i s reported.