BEHAVIORAL-EFFECTS OF FELBAMATE IN CHILDHOOD EPILEPTIC ENCEPHALOPATHY(LENNOX-GASTAUT SYNDROME)

The behavioral effects of felbamate were assessed in 20 persons (ages 2 to 19 years) who were participating in a compassionate plea protocol for children with Lennox-Gastaut syndrome. Parents completed a questi onnaire concerning aspects of behavioral change once all medications w ere in a constant regimen. Significant improvements were suggested in social functioning, intellectual functioning, motor functioning, atten tion and concentration, alertness, initiative, variability in performa nce, and memory. There was a tendency for these effects to reverse whe n the drug was discontinued.