STRUCTURE AND FUNCTION OF 5S RIBOSOMAL-RNA IN THE RIBOSOME

Together with specific proteins, 5S rRNA forms a universal structural domain of all cytoplasmic ribosomes. It is necessary for normal functi oning of the cell protein-synthesizing machinery. However, its functio n in protein biosynthesis is still unknown. The review considers moder n approaches to the macromolecular structure of free 5S rRNA. It is sh own that 5S rRNA is compacted in the ribosome. Own data are discussed concerning the topography of 5S rRNA in the ribosomal large subunit an d the ensuing hypothesis that 5S rRNA functions as a mediator between the ribosomal peptidyl transferase and EF-G-binding domains.