SYNTHESIS OF NOVEL POTASSIUM-SELECTIVE VALINOMYCINS

The synthesis is described of three aryl substituted valinomycins, in which the aryl groups are placed around the poles of the cyclodepsipep tide. In one synthesis a valinomycin is prepared carrying a pendant hy droxyphenyl residue. In this synthesis the use of the acetate function ality to protect the phenolic site in tyrosine is developed. The spect roscopic and electrochemical evidence indicating the potential importa nce of such modified valinomycins in the design of improved ion select ive electrodes is discussed.