AMPHOTERICIN-B RESPONSIVE SCEDOSPORIUM-APIOSPERMUM INFECTION IN A PATIENT WITH ACUTE MYELOID-LEUKEMIA

A 71 year old man with newly diagnosed acute myelomonocytic leukaemia developed a soft tissue infection of his foot during his first course of chemotherapy. Scedosporium apiospermum was isolated from the lesion , which resolved rapidly on treatment with intravenous amphotericin B despite being resistant in vitro to this agent. This observation sugge sts that sensitivity testing of S apiospermum should be interpreted wi th caution and that clinical response may be a better indicator of out come.