DRUG-MONITORING OF ANTIDEPRESSANT DRUGS I N PSYCHIATRY

The therapeutic drug monitoring of antidepressant drugs is of interest to adapt dosage regimens to reduce the number of non-responder patien ts, to reduce drug side effects and to detect noncompliant patients. A therapeutic range is defined for many of these drugs and their linear or non-linear kinetics are important parameters in clinical practice to define the posology. Some patients, because of when there is drug b iotransformation polymorphism, are exposed to drug accumulation a defi cit in isoenzymes of cytochrome P450. The existence of these isoenzyme s explains the possibility of non-linear kinetics and drug interaction s.