THE ROLE OF PLATELETS IN PROTECTIVE EFFEC TS OF VITAMIN-A, VITAMIN-E,VITAMIN-C AND VITAMIN-P COMBINATION IN THROMBINEMIA

White rat experiments have shown that combination of vitamins A, E, C and P diminishes thrombin-induced thrombocytopenia and low platelet ag gregation. This is explained by limited activation of free radical pro cesses initiated by thrombin in plasma, red cells and platelets. it wa s found that thrombin ability to activate lipid peroxidation is not re lated to coagulatory transformation of fibrinogen, but is rather due t o a direct contact of the enzyme with platelets. A protective effect o f vitamins-antioxidants in thrombinemia is likely to rest on their abi lity to restrict activation of free radical oxidation in platelets.