Am. Dygai et al., REGULATING EFFECTS OF HEMATOPOIESIS-INDUC ING MICROENVIRONMENT ON HEMATOPOIESIS - CHANGES DUE TO CYTOSTATICS, Gematologia i transfuziologia, 40(5), 1995, pp. 11-15
The study of bone marrow hemopoiesis, the count of hemopoietic precurs
or cells, bone marrow structural and functional organization, the leve
l of humoral stimulators and secretion by hemopoiesis-inducing microen
vironment (HIM) cells following a single injection of 5-fluorouracil,
cyclophosphamide or adriamycin has found out that cytostatic-related c
hanges in hemopoiesis recovery depend primarily on relationships betwe
en proliferation and differentiation of hemopoietic cells. These relat
ionships are dictated by the state of HIM cells. Enhanced functional a
ctivity of HIM elements in response to hemopoietic tissue damage cause
d by adriamycin or cyclophosphamide promotes rapid hemopoiesis regener
ation. At the same time, 5-fluorouracil gave rise to prolonged bone ma
rrow hypoplasia, severe disorder of microenvironment cell function.