REGULATING EFFECTS OF HEMATOPOIESIS-INDUC ING MICROENVIRONMENT ON HEMATOPOIESIS - CHANGES DUE TO CYTOSTATICS

The study of bone marrow hemopoiesis, the count of hemopoietic precurs or cells, bone marrow structural and functional organization, the leve l of humoral stimulators and secretion by hemopoiesis-inducing microen vironment (HIM) cells following a single injection of 5-fluorouracil, cyclophosphamide or adriamycin has found out that cytostatic-related c hanges in hemopoiesis recovery depend primarily on relationships betwe en proliferation and differentiation of hemopoietic cells. These relat ionships are dictated by the state of HIM cells. Enhanced functional a ctivity of HIM elements in response to hemopoietic tissue damage cause d by adriamycin or cyclophosphamide promotes rapid hemopoiesis regener ation. At the same time, 5-fluorouracil gave rise to prolonged bone ma rrow hypoplasia, severe disorder of microenvironment cell function.