A prospective study was made of environmental meters effects on unfavo
rable cardial and cerebral outcomes of rheumatic; fever (RF) assessed
functionally, biochemically and psychologically. Some of RF predisposi
ng meters (female sex, frequent nasopharyngeal infections, poor housin
g and occupational conditions) negatively affect outcomes of primary R
F and, contribute to emergence of valvular disease. The initial attack
of activity I or III degree, pronounced carditis, active rheumatic pr
ocess at discharge, recurrences, absence of year-round prophylaxis all
ow prognostication of valvular heart disease. The majority of the fact
ors promoting valvular and circulatory disorders also contribute to th
e onset of psychic abnormalities, astheno-organic syndrome, in particu
lar.