INHIBITORY EFFECT OF MAGNESIUM L-ASCORBYL-2-PHOSPHATE (VC-PMG) ON MELANOGENESIS IN-VITRO AND IN-VIVO

Background: An inhibitory effect of ascorbic acid (AsA) on melanogenes is has been described. However, AsA is quickly oxidized and decomposed in aqueous solution and thus is not generally useful as a depigmentin g agent. Objective: Our purpose was to examine the effect on pigmentat ion of magnesium-L-ascorbyl-2-phosphate (VC-PMG), a stable derivative of AsA. Methods: Percutaneous absorption of VC-PMG was examined in der matomed human skin, and its effect on melanin production by mammalian tyrosinase and human melanoma cells in culture was also measured. A 10 % VC-PMG cream was applied to the patients. Results: VC-PMG suppressed melanin formation by tyrosinase and melanoma cells. In situ experimen ts demonstrated that VC-PMG cream was absorbed into the epidermis and that 1.6% remained 48 hours after application. The lightening effect w as significant in 19 of 34 patients with chloasma or senile freckles a nd in 3 of 25 patients with normal skin. Conclusion: VC-PMG is effecti ve in reducing skin hyperpigmentation in some patients.