The burning mouth syndrome is characterized by burning and painful sen
sations of the mouth in the absence of significant mucosal abnormaliti
es. For patients in whom no causative factor can be identified, empiri
c antifungal, nutritional, and estrogen replacement therapy can be ini
tiated. If these fail, long-term therapy with antidepressants, benzodi
azepines, and clonazepam can be considered. Topical capsaicin and lase
r therapy have been reported beneficial in a few patients.