CIRRHOSIS AND GRANULOMATOUS HEPATITIS IND UCED BY LONG-TERM ADMINISTRATION OF ACETYLSALICYLIC-ACID

Authors
DABRIGEON G BLANC P DURAND L LARREY D MICHEL H
Citation
G. Dabrigeon et al., CIRRHOSIS AND GRANULOMATOUS HEPATITIS IND UCED BY LONG-TERM ADMINISTRATION OF ACETYLSALICYLIC-ACID, Gastroenterologie clinique et biologique, 19(11), 1995, pp. 944-947
Citations number
13
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Gastroenterologie clinique et biologique → ACNP
ISSN journal
03998320
Volume
19
Issue
11
Year of publication
1995
Pages
944 - 947
Database
ISI
SICI code
0399-8320(1995)19:11<944:CAGHIU>2.0.ZU;2-M
Abstract
We report the case of a 75-year-old woman who was hospitalized for ser um aminotransferase elevation. She had taken 1 g/d of salicylate thera py (Aspegic(R) 1000) for 5 years, clorazepate for 10 years, naftidrofu ryl for 8 months and quinapril for 3 months. Liver histology showed ci rrhosis and granulomatous hepatitis. Discontinuation of salicylate the rapy resulted in normalization of liver tests, although other drug adm inistration was pursued. This observation suggests that salicylate the rapy can induce cirrhosis.