Systemic mastocytosis is a chronic disease with proliferation of masto
cytes in organs separate from skin. We report the case of a systemic m
astocytosis revealed by a lymphocytic ascites in the absence of cutane
ous involvement. The diagnosis was established by the ultrastructural
examination of the bone marrow. Identification of few mastocytes in as
cites suggested a mast cell infiltration of the peritoneum. A treatmen
t by alpha-ab interferon was unsuccessful, and death rapidly occurred.