REFRACTORY THROMBOCYTOPENIA DUE TO ANTI-PL(A1) ANTIBODIES FOLLOWING AUTOLOGOUS PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION - CASE-REPORT ANDREVIEW OF LITERATURE

Authors
ROY V VERFAILLIE CM
Citation
V. Roy et Cm. Verfaillie, REFRACTORY THROMBOCYTOPENIA DUE TO ANTI-PL(A1) ANTIBODIES FOLLOWING AUTOLOGOUS PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION - CASE-REPORT ANDREVIEW OF LITERATURE, Bone marrow transplantation, 17(1), 1996, pp. 115-117
Citations number
8
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
17
Issue
1
Year of publication
1996
Pages
115 - 117
Database
ISI
SICI code
0268-3369(1996)17:1<115:RTDTAA>2.0.ZU;2-V
Abstract
A 43-year-old woman developed life-threatening refractory thrombocytop enia following autologous peripheral blood stem cell transplantation f or metastatic breast carcinoma. Anti-PL(A1) antibodies were demonstrat ed in the patient's plasma. Treatment with intravenous immunoglobulin and transfusion of PL(A1)-negative blood products restored platelet re sponsiveness, PL(A1) alloantibodies should be considered as a possible cause of severe refractory thrombocytopenia in marrow transplant pati ents. It is important to make this diagnosis as the mainstay of treatm ent is the avoidance of blood products from PL(A1)-positive donors (98 % of the population).