HIGH-LEVEL SENSITIVITY OF QUANTITATIVE PP65 CYTOMEGALOVIRUS (CMV) ANTIGENEMIA ASSAY FOR DIAGNOSIS OF CMV DISEASE IN AIDS PATIENTS AND FOLLOW-UP

Cytomegalovirus (CMV) antigenemia was evaluated in 174 patients positi ve for human immunodeficiency virus. Antigenemia could be detected in 96.7% of patients with CMV disease, 76.9% of patients suffering from a relapse of the disease, and 11.4% of asymptomatic patients with CD4 l evels of <100 cells per mu l. No antigenemia was detected in patients with CD4 levels of 250 to 500 cells per mu l. Specificity and the posi tive predictive value for CMV disease were increased only if more than 5 positive cells per slide were considered. However, CMV disease may also occur in patients with low-grade antigenemia.