Yv. Bobryshev et Rsa. Lord, DETECTION OF VASCULAR DENDRITIC CELLS AND EXTRACELLULAR CALCIUM-BINDING PROTEIN S-100 IN FOCI OF CALCIFICATION IN HUMAN ARTERIES, Acta histochemica et cytochemica, 28(4), 1995, pp. 371-380
A new explanation of why calcification develops in arterial vessels is
proposed. Some of recently described CD1a(+)/S-100(+) vascular dendri
tic cells have been found to undergo destruction in athero-prone areas
of the aorta and in atherosclerotic lesions (Bobryshev and Lord, Arch
. Histol. Cytol., 1995). Lysis of these vascular dendritic cells shoul
d release their cellular components into the extracellular space, incl
uding S-100 which belongs to the family of calcium-binding proteins. I
n the present study we examined the possible association of vascular d
endritic cells with calcification in atherosclerosis and found that va
scular dendritic cells were present in early foci of calcification in
the arterial intima and in atherosclerotic lesions. This finding sugge
sts the possible involvement of vascular dendritic cells in the proces
s of arterial wall calcification. Vascular dendritic cells and calcify
ing vascular cells may be related where a subset of vascular dendritic
cells represents calcifying vascular cells in the arterial wall. Extr
acellularly distributed S-100 protein was also found in association wi
th early calcified deposits. The detection of calcium-binding S-100 pr
otein in the extracellular matrix suggests that molecular mechanisms a
re involved in atherosclerotic calcification, which is quite different
from the previously postulated mechanisms involving bone-associated p
roteins.