K. Raslova et M. Huckova, DYSLIPOPROTEINEMIA IN CHILDREN WITH OR WITHOUT FAMILY HISTORY OF PREMATURE MYOCARDIAL-INFARCTION, Physiological Research, 44(6), 1995, pp. 429-432
In order to examine the relationship between certain risk factors for
atherosclerosis and family history of myocardial infarction, we compar
ed a group of children (n=51) whose parents had survived myocardial in
farction (n=34) with a control group of children (n=90) with a negativ
e family history of atherosclerosis (62 parents). The study revealed a
surprising fact that 26.7 % of control children had hypercholesterola
emia compared to 15.7 % incidence in ''risk'' children. ''Risk'' child
ren differed from the controls most in the ape-A-l levels and a higher
risk index expressed by the proportion of apo-B:apo-A-l (1.22, 1.34 g
/l, p=0.001, 0.58, 0.46, p=0.05, respectively). Since the most frequen
t primary hyperlipoproteinaemia in myocardial infarction families was
familial combined hyperlipoproteinaemia, we assume that this condition
may be presented in affected children by an unfavourable proportion o
f apolipoproteins of the lipoprotein classes.