DYSLIPOPROTEINEMIA IN CHILDREN WITH OR WITHOUT FAMILY HISTORY OF PREMATURE MYOCARDIAL-INFARCTION

In order to examine the relationship between certain risk factors for atherosclerosis and family history of myocardial infarction, we compar ed a group of children (n=51) whose parents had survived myocardial in farction (n=34) with a control group of children (n=90) with a negativ e family history of atherosclerosis (62 parents). The study revealed a surprising fact that 26.7 % of control children had hypercholesterola emia compared to 15.7 % incidence in ''risk'' children. ''Risk'' child ren differed from the controls most in the ape-A-l levels and a higher risk index expressed by the proportion of apo-B:apo-A-l (1.22, 1.34 g /l, p=0.001, 0.58, 0.46, p=0.05, respectively). Since the most frequen t primary hyperlipoproteinaemia in myocardial infarction families was familial combined hyperlipoproteinaemia, we assume that this condition may be presented in affected children by an unfavourable proportion o f apolipoproteins of the lipoprotein classes.