2 PAIRS OF MALE MONOZYGOTIC TWINS DISCORDANT FOR WIEDEMANN-BECKWITH SYNDROME

Wiedemann-Beckwith syndrome (WBS) is a congenital anomaly syndrome whi ch classically consists of exomphalos, macroglossia, and gigantism, Th e syndrome is also associated with a variety of minor anomalies and af fected individuals have an increased risk of developing rare embryonal cell tumors, To date, 15 monozygotic (MZ) twin pairs have been report ed of which 13 are discordant for WBS, All except one pair of the disc ordant WBS twin pairs have been female. We report two pairs of male MZ twins, each discordant for WBS. (C) 1996 Wiley-Liss, Inc.