EFFECT OF SOLVATE FORMATION ON LYOAVAILABILITY OF LORAZEPAM DURING WET GRANULATION

Authors
JOACHIM J OPOTA DO JOACHIM G REYNIER JP MONGES P MAURY L
Citation
J. Joachim et al., EFFECT OF SOLVATE FORMATION ON LYOAVAILABILITY OF LORAZEPAM DURING WET GRANULATION, STP pharma sciences, 5(6), 1995, pp. 486-488
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
STP pharma sciences → ACNP
ISSN journal
11571489
Volume
5
Issue
6
Year of publication
1995
Pages
486 - 488
Database
ISI
SICI code
1157-1489(1995)5:6<486:EOSFOL>2.0.ZU;2-X
Abstract
During granule and tablet formulation some ingredients can affect the physical properties of the drug. In order to study the effects of gran ulating agents on certain drugs, two different methods of manufacture were used. Lorazepam was chosen as the drug. We studied the dissolutio n kinetics of the formulas obtained by dry and wet granulation, in ord er to investigate possible modifications in drug release. Infrared spe ctroscopy showed a pseudopolymorphic form of lorazepam.