ELECTROENCEPHALOGRAPHIC FINDINGS WITH LOW-DOSE CLOZAPINE TREATMENT INPSYCHOTIC PARKINSONIAN-PATIENTS

Twenty patients with Parkinson's disease (PD), who developed delusions and psychotic behavior, underwent electroencephalogram (EEG) recordin gs before and during treatment with low-dose clozapine. Resolution of the psychotic features was observed in all cases. The EEG was unaltere d in 15, whereas five patients exhibited increased generalized or foca l slowing when compared with the pretreatment tracings. These findings contrast with the high incidence of EEG abnormalities, including epil eptiform activity, which are observed when larger doses of clozapine a re used in schizophrenic patients, but they underscore that even in lo w doses, clozapine may cause EEG changes.