MODULATION OF SERCA2 ACTIVITY - REGULATED SPLICING AND INTERACTION WITH PHOSPHOLAMBAN

Authors
VERBOOMEN H MERTENS L EGGERMONT J WUYTACK F VANDENBOSCH L
Citation
H. Verboomen et al., MODULATION OF SERCA2 ACTIVITY - REGULATED SPLICING AND INTERACTION WITH PHOSPHOLAMBAN, Bioscience reports, 15(5), 1995, pp. 307-315
Citations number
48
Categorie Soggetti
Biology
Journal title
Bioscience reports → ACNP
ISSN journal
01448463
Volume
15
Issue
5
Year of publication
1995
Pages
307 - 315
Database
ISI
SICI code
0144-8463(1995)15:5<307:MOSA-R>2.0.ZU;2-N
Abstract
Ca2+-uptake into intracellular stores is mediated by the sarco/endopla smic reticulum Ca2+ ATPases (SERCAs). This review deals first with the gene structural and the characterization of the tissue-specific SERCA 2 transcript processing. Secondly, the two different protein isoforms and their regulation are described. Finally, this review ends with a d iscussion on the possible physiological role of the SERCA2 isoform div ersity.