LUMINAL CALCIUM REGULATION OF CALCIUM-RELEASE FROM SARCOPLASMIC-RETICULUM

This article discusses how changes in luminal calcium concentration af fect calcium release rates from triad-enriched sarcoplasmic reticulum vesicles, as well as single channel opening probability of the ryanodi ne receptor/calcium release channels incorporated in bilayers. The pos sible participation of calsequestrin, or of other luminal proteins of sarcoplasmic reticulum in this regulation is addressed. A comparison w ith the regulation by luminal calcium of calcium release mediated by t he inositol 1,4,5-trisphosphate receptor/calcium channel is presented as well.