A sample of 301 amphetamine users were interviewed about their experie
nces of psychological symptoms prior to, and subsequent to, their init
iation of amphetamine use. Psychological morbidity was common, with 44
% scoring greater than a conservative cut-off of 8 on the General Heal
th Questionnaire. The most commonly reported symptoms subsequent to th
e onset of amphetamine use were depression (79%), anxiety (76%), paran
oia (52%), hallucinations (46%) and violent behaviour (44%). All these
symptoms increased in prevalence after the onset of amphetamine use.
Route and frequency of amphetamine administration were significant ind
ependent predictors of overall psychological morbidity, while route of
administration was related to the experience of hallucinations, viole
nt behaviour and paranoia. The avoidance of injection as a route of ad
ministration and the use of amphetamines less than weekly are recommen
ded as steps that users can take to reduce the psychological seguelae
of amphetamine use.