APPROACHES TO SHORT-ACTING NEUROMUSCULAR BLOCKING-AGENTS - NONSYMMETRICAL BIS-TETRAHYDROISOQUINOLINIUM MONOESTERS AND DIESTERS

Authors
DHAR NC MAEHR RB MASTERSON LA MIDGLEY JM STENLAKE JB WASTILA WB
Citation
Nc. Dhar et al., APPROACHES TO SHORT-ACTING NEUROMUSCULAR BLOCKING-AGENTS - NONSYMMETRICAL BIS-TETRAHYDROISOQUINOLINIUM MONOESTERS AND DIESTERS, Journal of medicinal chemistry, 39(2), 1996, pp. 556-561
Citations number
10
Categorie Soggetti
Chemistry Medicinal
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
39
Issue
2
Year of publication
1996
Pages
556 - 561
Database
ISI
SICI code
0022-2623(1996)39:2<556:ATSNB->2.0.ZU;2-T
Abstract
Nonsymmetrical bisquaternary mono- and diesters combining the potency- enhancing properties of the (1R)-laudanosinium group with a second unh indered quaternary ammonium moiety have been studied as a means of pro moting short action with high-potency neuromuscular block. Atracurium- related nonsymmetrical diesters showed high potency, freedom from vaga l blockade at neuromuscular blocking doses, and short action. Nonsymme trical monoesters were short acting but showed varying degrees of vaga l block.